Estrogen nhances malignant phenotypes in human salivary adenoid cystic carcinoma cells

Tomoki Sumida, Akiko Ishikawa, Yu Kamata, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background/Aim: Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatment target or not. Materials and Methods: Adenoid cystic carcinoma (ACC) ACCM cells, were used. The specific cell line lacks estrogen receptor (ER). ER was introduced in ACCM cells, and the effect of 17estradiol (E2) was investigated on cell proliferation, cell-cycle distribution, and cell motility. Results: E2 induced cell proliferation, and the S-phase fraction increased in a dose-dependent manner. Cell motility was also up-regulated compared to control cells. Conclusion: The estrogen/ER system up-regulated malignant phenotypes in ER-positive ACC, and hormone therapy may have a potential as effective treatment for this malignancy.

Original languageEnglish
Pages (from-to)2793-2798
Number of pages6
JournalAnticancer research
Issue number6
Publication statusPublished - Jun 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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