Establishment of vertebrate left-right asymmetry

Hiroshi Hamada, Chikara Meno, Daisuke Watanabe, Yukio Saijoh

Research output: Contribution to journalReview articlepeer-review

458 Citations (Scopus)


The generation of morphological, such as left-right, asymmetry during development is an integral part of the establishment of a body plan. Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-β-related molecules, have a central role in generating asymmetric signals. Although the initial mechanism of symmetry breaking remains unknown, developmental biologists are beginning to analyse the pathway that leads to left-right asymmetry establishment and maintenance.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalNature Reviews Genetics
Issue number2
Publication statusPublished - 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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