Establishment and characterization of PTHrP-producing human pancreatic cancer cell line

Y. Nishi; M. Haji; R. Takayanagi; H. Iguchi; T. Shimazoe; J. Hirata; H. Nawata

doi:10.3892/ijo.5.1.33

Establishment and characterization of PTHrP-producing human pancreatic cancer cell line

Y. Nishi, M. Haji, R. Takayanagi, H. Iguchi, T. Shimazoe, J. Hirata, H. Nawata

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Human pancreatic ductal cell carcinoma cell line, which can secrete parathyroid hormone-related peptide (PTHrP), designated as KP 4, and its daughter cell lines with different PTHrP-secreting activities, termed KP 4-1 and KP 4-2, have been established in tissue culture. KP 4 cells were able to form tumors in nude mice. The absolute production rate of PTHrP in KP 4-1 was 5 to 10 times higher than that in KP 4-2. Similarly, the level of PTHrP mRNA in KP 4-1 was significantly higher than that in KP 4-2. KP 4-2 cells exhibited more rapid growth than KP 4 and KP 4-2 vitro. Our established cell lines should provide a useful system to study the regulation of PTHrP production and its pathophysiological roles.

Original language	English
Pages (from-to)	33-39
Number of pages	7
Journal	International journal of oncology
Volume	5
Issue number	1
DOIs	https://doi.org/10.3892/ijo.5.1.33
Publication status	Published - 1994

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.3892/ijo.5.1.33

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title = "Establishment and characterization of PTHrP-producing human pancreatic cancer cell line",

abstract = "Human pancreatic ductal cell carcinoma cell line, which can secrete parathyroid hormone-related peptide (PTHrP), designated as KP 4, and its daughter cell lines with different PTHrP-secreting activities, termed KP 4-1 and KP 4-2, have been established in tissue culture. KP 4 cells were able to form tumors in nude mice. The absolute production rate of PTHrP in KP 4-1 was 5 to 10 times higher than that in KP 4-2. Similarly, the level of PTHrP mRNA in KP 4-1 was significantly higher than that in KP 4-2. KP 4-2 cells exhibited more rapid growth than KP 4 and KP 4-2 vitro. Our established cell lines should provide a useful system to study the regulation of PTHrP production and its pathophysiological roles.",

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T1 - Establishment and characterization of PTHrP-producing human pancreatic cancer cell line

AU - Nishi, Y.

AU - Haji, M.

AU - Takayanagi, R.

AU - Iguchi, H.

AU - Shimazoe, T.

AU - Hirata, J.

AU - Nawata, H.

PY - 1994

Y1 - 1994

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AB - Human pancreatic ductal cell carcinoma cell line, which can secrete parathyroid hormone-related peptide (PTHrP), designated as KP 4, and its daughter cell lines with different PTHrP-secreting activities, termed KP 4-1 and KP 4-2, have been established in tissue culture. KP 4 cells were able to form tumors in nude mice. The absolute production rate of PTHrP in KP 4-1 was 5 to 10 times higher than that in KP 4-2. Similarly, the level of PTHrP mRNA in KP 4-1 was significantly higher than that in KP 4-2. KP 4-2 cells exhibited more rapid growth than KP 4 and KP 4-2 vitro. Our established cell lines should provide a useful system to study the regulation of PTHrP production and its pathophysiological roles.

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Establishment and characterization of PTHrP-producing human pancreatic cancer cell line

Abstract

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