Erratum for Compressive Force-Produced CCN2 Induces Osteocyte Apoptosis through ERK1/2 Pathway (Journal of Bone and Mineral Research, (2014), 29, (1244-57), 10.1002/jbmr.2115)

Kenji Hoshi, Harumi Kawaki, Ichiro Takahashi, Nobuo Takeshita, Masahiro Seiryu, Sakhr A. Murshid, Taisuke Masuda, Takahisa Anada, Ryushi Kato, Hideki Kitaura, Osamu Suzuki, Teruko Takano-Yamamoto

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)


A reader of JBMR contacted the journal with concerns of duplication with shifts and slight magnification in Fig. 5B in ref 1. The image appeared to show duplication of p38 MAPK staining, magnification adjustment, and enhanced brightness in the Comp(+) 6-hour image of Merge. The authors reported that they erroneously saved a sample image to the wrong folder, causing the duplication of PI image of p-p38 MAPK staining in Fig. 5B. 5 Fig (Figure presented.) Activation of ERK1/2 in osteocytes by compressive force loading. (A, B) Phosphorylation of ERK1/2 (A) and p38 MAPK (B) in loaded osteocytes. The loading period was 6 hours. Comp = compressive force loading. Arrowhead = osteocyte with nuclear translocation. Scale bars = 20mm. (C) Effects of PD98059 (left) and SB239063 (right) on osteocyte apoptosis induced by loading. The loading period was 6 hours. Each bar represents the means ± SE of three independent evaluations. *p<0.05, significantly different from control. The authors provided original and supplemental data for the editors and provided a corrected Fig. 5, shown below. The new Fig. 5A and B uses images of PI, ERK, p-ERK, p38 MAPK, p-p38 MAPK, and Merge, taken from samples for each group of Comp(-) 0 hours, Comp(-) 6 hours, and Comp(+) 6 hours during experiments at that time. Immunofluorescence staining in Fig. 5A and B showed that phosphorylation of ERK1/2 was promoted in loaded osteocytes (Fig. 5A), whereas phosphorylation of p38 MAPK was slightly enhanced after loading (Fig. 5B). There were some osteocytes showing nuclear translocation of p-ERK1/2. The authors confirmed that no revisions to the original text are needed.

Original languageEnglish
Pages (from-to)2303-2304
Number of pages2
JournalJournal of Bone and Mineral Research
Issue number11
Publication statusPublished - Nov 2020

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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