TY - JOUR
T1 - Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia
AU - Ohga, S.
AU - Kanaya, Y.
AU - Maki, H.
AU - Takada, H.
AU - Ohshima, K.
AU - Kanda, M.
AU - Nomura, A.
AU - Suminoe, A.
AU - Matsuzaki, A.
AU - Hara, T.
N1 - Funding Information:
This work was supported in part by a grant (to S Ohga) from the Ministry of Education, Science and Culture of Japan. We thank Mr Ryu Iwasaki, Miss Noriko Kobayashi (Mitsubishi Kagaku Bio-Clinical Laboratories, Inc. Tokyo) for genetic analyses.
PY - 2000
Y1 - 2000
N2 - A 7-year-old boy with Diamond-Blackfan anemia (DBA) developed lymphoproliferative disease (LPD) after a cord blood transplant (CBT). 3.1 x 107/kg mononuclear cells from an HLA one-locus mismatched CB were transplanted after conditioning with total body irradiation (8 Gy), cyclophosphamide (200 mg/kg) and antithymocyte globulin (10 mg/kg). Complete engraftment occurred on day 33 post transplant. Despite the resolution of grade II graft-versus-host disease (GVHD), he died of lymphoma on day 130 post transplant. The tumor was of donor origin, indicating clonal proliferation of Epstein-Barr virus (EBV)-infected B cells. This is the first report of EBV-LPD after CBT. Post-transplant LPD can be a serious EBV-associated complication of CB grafts.
AB - A 7-year-old boy with Diamond-Blackfan anemia (DBA) developed lymphoproliferative disease (LPD) after a cord blood transplant (CBT). 3.1 x 107/kg mononuclear cells from an HLA one-locus mismatched CB were transplanted after conditioning with total body irradiation (8 Gy), cyclophosphamide (200 mg/kg) and antithymocyte globulin (10 mg/kg). Complete engraftment occurred on day 33 post transplant. Despite the resolution of grade II graft-versus-host disease (GVHD), he died of lymphoma on day 130 post transplant. The tumor was of donor origin, indicating clonal proliferation of Epstein-Barr virus (EBV)-infected B cells. This is the first report of EBV-LPD after CBT. Post-transplant LPD can be a serious EBV-associated complication of CB grafts.
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U2 - 10.1038/sj.bmt.1702138
DO - 10.1038/sj.bmt.1702138
M3 - Article
C2 - 10673683
AN - SCOPUS:0033951761
SN - 0268-3369
VL - 25
SP - 209
EP - 212
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 2
ER -