Epithelial cell lines in the field of dental research: Review

Satoshi Fukumoto, Makiko Arakaki, Tsutomu Iwamoto, Aya Yamada, Ryoko Miyamoto, Masahiro Naruse, Takashi Nakamura

Research output: Chapter in Book/Report/Conference proceedingChapter


The interaction between the epithelium and mesenchyme induces specific molecular and cellular changes that lead to organogenesis. These interactions are particularly crucial during the initiation of the development of ectodermal organs, such as teeth, skin, hair, and mammary and prostate glands. The oral epithelium provides the initial signaling for neuronal crest-derived ectomesenchyme development, and then both tissues interact during tooth formation. Various transcription factors, growth factors, and extracellular matrices are expressed by enamel matrix-producing ameloblasts during tooth development. Dental epithelium was lost after tooth eruption in human. To analysis of dental cell proliferation and differentiation, we should use the dental epithelial cells from tooth germ, for example third molar, supernumerary tooth or continuous erupting rodent incisor. However, primary culture of dental epithelium has a limited number of cells and passage times. Because of these reasons, cell lines from dental tissue are useful to clear the molecular mechanism of these processes. Here we introduce cell lines from dental tissues, especially dental epithelium.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Number of pages7
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
Publication statusPublished - Jan 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Dentistry


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