Epigenetic regulation of neural stem cell fate during corticogenesis

Chai MuhChyi, Berry Juliandi, Taito Matsuda, Kinichi Nakashima

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.

Original languageEnglish
Pages (from-to)424-433
Number of pages10
JournalInternational Journal of Developmental Neuroscience
Issue number6
Publication statusPublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology


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