TY - CHAP
T1 - Epigenetic Regulation of Human Neural Stem Cell Differentiation
AU - Honda, Mizuki
AU - Nakashima, Kinichi
AU - Katada, Sayako
PY - 2018
Y1 - 2018
N2 - Emerging evidence has demonstrated that epigenetic programs influence many aspects of neural stem cell (NSC) behavior, including proliferation and differentiation. It is becoming apparent that epigenetic mechanisms, such as DNA methylation, histone modifications, and noncoding RNA expression, are spatiotemporally regulated and that these intracellular programs, in concert with extracellular signals, ensure appropriate gene activation. Here we summarize recent advances in understanding of the epigenetic regulation of human NSCs directly isolated from the brain or produced from pluripotent stem cells (embryonic and induced pluripotent stem cells, respectively).
AB - Emerging evidence has demonstrated that epigenetic programs influence many aspects of neural stem cell (NSC) behavior, including proliferation and differentiation. It is becoming apparent that epigenetic mechanisms, such as DNA methylation, histone modifications, and noncoding RNA expression, are spatiotemporally regulated and that these intracellular programs, in concert with extracellular signals, ensure appropriate gene activation. Here we summarize recent advances in understanding of the epigenetic regulation of human NSCs directly isolated from the brain or produced from pluripotent stem cells (embryonic and induced pluripotent stem cells, respectively).
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UR - http://www.scopus.com/inward/citedby.url?scp=85053994388&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-93485-3_5
DO - 10.1007/978-3-319-93485-3_5
M3 - Chapter
C2 - 30209657
AN - SCOPUS:85053994388
T3 - Results and Problems in Cell Differentiation
SP - 125
EP - 136
BT - Results and Problems in Cell Differentiation
PB - Springer Verlag
ER -