Eosinophilic fasciitis associated with Borrelia afzelii infection

Osamu Kikuchi, Hiroyuki Murai, Koji Ikezoe, Masakazu Kawajiri, Yasumasa Ohyagi, Emiko Isogai, Jun Ichi Kira

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A 58-year-old woman suffered from stiffness, swelling, rubor and muscle pain in the extremities one month after she climbed a mountain in Kyushu, an island in southern Japan. On admission, mild proximal weakness was present in the extremities. Her range of motion in the extremities was limited due to firm skin and subcutaneous stiffness which was similar to scleroderma. She showed peripheral blood eosinophilia and hypergammaglobulinemia as well as a high erythrocyte sedimentation rate. An IgM antibody against Borrelia afzelii was positive. MRI of the skeletal muscles demonstrated enhancing fascia around the biceps brachii muscle, and a biopsy specimen revealed perivascular infiltration of mononuclear cells within the hypertrophic fascia. Eosinophilic infiltration was absent. We treated the patient with prednisolone, doxycycline and amoxicillin, which alleviated the symptoms. This is the first report to show that Borrelia afzelii was involved in eosinophilic fasciitis.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalClinical Neurology
Issue number4-5
Publication statusPublished - Apr 2004

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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