Enzymatic synthesis of sugar amino acid esters in organic solvents

Tatsuo Maruyama, Shin Ichiro Nagasawa, Masahiro Goto

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    26 Citations (Scopus)


    The enzymatic synthesis of sugar amino acid esters in polar organic solvents was studied using surfactant-enzyme complexes, which were previously developed as a highly active biocatalyst in organic solvents. Of the several lipases and proteases tested, the surfactant-subtilisin complex exhibited the highest synthetic activity in pyridine. The amino acid was regioselectively introduced at the C-6 position of D-glucose and at the C-6' of maltose by the surfactant-subtilisin complex. This biocatalyst was found to effectively catalyze the synthesis of various sugar amino acid esters in a polar organic solvent.

    Original languageEnglish
    Pages (from-to)357-361
    Number of pages5
    JournalJournal of Bioscience and Bioengineering
    Issue number4
    Publication statusPublished - 2002

    All Science Journal Classification (ASJC) codes

    • Biotechnology
    • Bioengineering
    • Applied Microbiology and Biotechnology


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