TY - JOUR
T1 - Environmental impacts on brain functions
T2 - Low dose effects of bisphenol A during perinatal critical period
AU - Fujimoto, T.
AU - Kubo, K.
AU - Aou, S.
PY - 2007/7
Y1 - 2007/7
N2 - It is well known that the perinatal developing brain is vulnerable to environmental chemicals such as bisphenol A (BPA). Recent studies have focused on the low dose effects of BPA on the central nervous system (CNS). Sexual dimorphism in the rat's brain and behaviors, such as locus coeruleus (LC) and open-field behaviors, were sensitively altered by BPA in a sex-dependent manner. This chemical also enhanced the depressive response. It suggests that the developing brain, including the noradrenergic LC cell, is highly sensitive to environmental chemicals, which induces diverse behavioral alterations.
AB - It is well known that the perinatal developing brain is vulnerable to environmental chemicals such as bisphenol A (BPA). Recent studies have focused on the low dose effects of BPA on the central nervous system (CNS). Sexual dimorphism in the rat's brain and behaviors, such as locus coeruleus (LC) and open-field behaviors, were sensitively altered by BPA in a sex-dependent manner. This chemical also enhanced the depressive response. It suggests that the developing brain, including the noradrenergic LC cell, is highly sensitive to environmental chemicals, which induces diverse behavioral alterations.
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U2 - 10.1016/j.ics.2006.12.002
DO - 10.1016/j.ics.2006.12.002
M3 - Article
AN - SCOPUS:34250016789
SN - 0531-5131
VL - 1301
SP - 226
EP - 229
JO - International Congress Series
JF - International Congress Series
ER -