Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats

T. Shimazoe, J. Ishida, M. Maetani, T. Yakabe, M. Yamaguchi, K. Miyasaka, A. Kono, S. Watanabe, A. Funakoshi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The term for re-entrainment to a new light-dark cycle in streptozotocin (STZ)-induced diabetic rats was significantly longer than that in control rats. In STZ-induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application. Therefore, 5-HT function in the hypothalamus is thought to be decreased in STZ-induced diabetic rats. These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore, 5-HT mechanisms may play an important role in the maintenance of this function.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalJapanese Journal of Pharmacology
Issue number4
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Pharmacology


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