The degree of enantioselection by second-generation Mn-salen complexes was found to depend upon the conformation of their ligand and substrate nucleophilicity. Oxidation of usual olefins was better effected by using (R,S)-Mn-salen complexes as catalysts, while that of more nucleophilic ones was achieved by using (R,R)-Mn-salen complexes. This phenomenon was explained by analyzing the enthalpy and entropy factors of the reactions. (C) 2000 Elsevier Science Ltd.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry