TY - JOUR
T1 - Enhancement of TFO triplex formation by conjugation with pyrene via click chemistry
AU - Taniguchi, Yosuke
AU - Tomizaki, Akira
AU - Matsueda, Nozomu
AU - Okamura, Hidenori
AU - Sasaki, Shigeki
N1 - Publisher Copyright:
© 2015 The Pharmaceutical Society of Japan.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-Omethyl- 1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.
AB - This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-Omethyl- 1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.
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U2 - 10.1248/cpb.c15-00570
DO - 10.1248/cpb.c15-00570
M3 - Article
C2 - 26521856
AN - SCOPUS:84955454461
SN - 0009-2363
VL - 63
SP - 920
EP - 926
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 11
ER -