Enhancement of reaction efficiency by functionalized alcohols on gold(I)-catalyzed intermodular hydroalkoxylation of unactivated olefins

Toshifumi Hirai; Aklyuki Hamasaki; Aki Nakamura; Makoto Tokunaga

doi:10.1021/ol9023166

Enhancement of reaction efficiency by functionalized alcohols on gold(I)-catalyzed intermodular hydroalkoxylation of unactivated olefins

Toshifumi Hirai, Aklyuki Hamasaki, Aki Nakamura, Makoto Tokunaga

Multidisciplinary chemistry

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

"Chemical Equation Presented" Intermolecular hydroalkoxylation of unactivated olefins catalyzed by the combination of gold(I) and electron deficient phosphine ligands has been developed. Although pairings of unactivated olefins and common aliphatic alcohols gave unsatisfactory results In gold catalyzed hydroalkoxylations, the use of alcohol substrates bearing coordination functionalities such as halogen or alkoxy groups showed great improvement of reactivity.

Original language	English
Pages (from-to)	5510-5513
Number of pages	4
Journal	Organic letters
Volume	11
Issue number	23
DOIs	https://doi.org/10.1021/ol9023166
Publication status	Published - Dec 3 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol9023166

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abstract = "{"}Chemical Equation Presented{"} Intermolecular hydroalkoxylation of unactivated olefins catalyzed by the combination of gold(I) and electron deficient phosphine ligands has been developed. Although pairings of unactivated olefins and common aliphatic alcohols gave unsatisfactory results In gold catalyzed hydroalkoxylations, the use of alcohol substrates bearing coordination functionalities such as halogen or alkoxy groups showed great improvement of reactivity.",

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T1 - Enhancement of reaction efficiency by functionalized alcohols on gold(I)-catalyzed intermodular hydroalkoxylation of unactivated olefins

AU - Hirai, Toshifumi

AU - Hamasaki, Aklyuki

AU - Nakamura, Aki

AU - Tokunaga, Makoto

PY - 2009/12/3

Y1 - 2009/12/3

N2 - "Chemical Equation Presented" Intermolecular hydroalkoxylation of unactivated olefins catalyzed by the combination of gold(I) and electron deficient phosphine ligands has been developed. Although pairings of unactivated olefins and common aliphatic alcohols gave unsatisfactory results In gold catalyzed hydroalkoxylations, the use of alcohol substrates bearing coordination functionalities such as halogen or alkoxy groups showed great improvement of reactivity.

AB - "Chemical Equation Presented" Intermolecular hydroalkoxylation of unactivated olefins catalyzed by the combination of gold(I) and electron deficient phosphine ligands has been developed. Although pairings of unactivated olefins and common aliphatic alcohols gave unsatisfactory results In gold catalyzed hydroalkoxylations, the use of alcohol substrates bearing coordination functionalities such as halogen or alkoxy groups showed great improvement of reactivity.

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Enhancement of reaction efficiency by functionalized alcohols on gold(I)-catalyzed intermodular hydroalkoxylation of unactivated olefins

Abstract

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