Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid

Asanori Yara; Takashi Yaeno; Jean Luc Montillet; Morifumi Hasegawa; Shigemi Seo; Kensuke Kusumi; Koh Iba

doi:10.1016/j.bbrc.2008.03.083

Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid

Asanori Yara
, Takashi Yaeno
, Jean Luc Montillet
, Morifumi Hasegawa
, Shigemi Seo
, Kensuke Kusumi
, Koh Iba

Informational Biology

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Linoleic acid (18:2) and linolenic acid (18:3) are sources for various oxidized metabolites called oxylipins, some of which inhibit growth of fungal pathogens. In a previous study, we found disease resistance to rice blast fungus Magnaporthe grisea enhanced in 18:2-accumulating transgenic rice (F78Ri) in which the conversion from 18:2 to 18:3 was suppressed. Here, we demonstrate that 18:2-derived hydroperoxides and hydroxides (HPODEs and HODEs, respectively) inhibit growth of M. grisea more strongly than their 18:3-derived counterparts. Furthermore, in F78Ri plants, the endogenous levels of HPODEs and HODEs increased significantly, compared with wild-type plants. These results suggest that the increased accumulation of antifungal oxylipins, such as HPODEs and HODEs, causes the enhancement of disease resistance against M. grisea.

Original language	English
Pages (from-to)	344-347
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	370
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2008.03.083
Publication status	Published - May 30 2008

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2008.03.083

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@article{a74b43f7ede84dd39699c9efbd96c4c0,

title = "Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid",

abstract = "Linoleic acid (18:2) and linolenic acid (18:3) are sources for various oxidized metabolites called oxylipins, some of which inhibit growth of fungal pathogens. In a previous study, we found disease resistance to rice blast fungus Magnaporthe grisea enhanced in 18:2-accumulating transgenic rice (F78Ri) in which the conversion from 18:2 to 18:3 was suppressed. Here, we demonstrate that 18:2-derived hydroperoxides and hydroxides (HPODEs and HODEs, respectively) inhibit growth of M. grisea more strongly than their 18:3-derived counterparts. Furthermore, in F78Ri plants, the endogenous levels of HPODEs and HODEs increased significantly, compared with wild-type plants. These results suggest that the increased accumulation of antifungal oxylipins, such as HPODEs and HODEs, causes the enhancement of disease resistance against M. grisea.",

author = "Asanori Yara and Takashi Yaeno and Montillet, \{Jean Luc\} and Morifumi Hasegawa and Shigemi Seo and Kensuke Kusumi and Koh Iba",

note = "Funding Information: We thank Prof. Hiroyuki Ohta (Tokyo Institute of Technology) for critical reading and helpful discussion. This research was supported by CREST, JST, and the Ministry of Agriculture, Forestry, and Fisheries of Japan (Rice Genome Project IP-5005) and the Japan Society of the Promotion of Science (17370019) grants.",

year = "2008",

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doi = "10.1016/j.bbrc.2008.03.083",

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AU - Yara, Asanori

AU - Yaeno, Takashi

AU - Montillet, Jean Luc

AU - Hasegawa, Morifumi

AU - Seo, Shigemi

AU - Kusumi, Kensuke

AU - Iba, Koh

N1 - Funding Information: We thank Prof. Hiroyuki Ohta (Tokyo Institute of Technology) for critical reading and helpful discussion. This research was supported by CREST, JST, and the Ministry of Agriculture, Forestry, and Fisheries of Japan (Rice Genome Project IP-5005) and the Japan Society of the Promotion of Science (17370019) grants.

PY - 2008/5/30

Y1 - 2008/5/30

N2 - Linoleic acid (18:2) and linolenic acid (18:3) are sources for various oxidized metabolites called oxylipins, some of which inhibit growth of fungal pathogens. In a previous study, we found disease resistance to rice blast fungus Magnaporthe grisea enhanced in 18:2-accumulating transgenic rice (F78Ri) in which the conversion from 18:2 to 18:3 was suppressed. Here, we demonstrate that 18:2-derived hydroperoxides and hydroxides (HPODEs and HODEs, respectively) inhibit growth of M. grisea more strongly than their 18:3-derived counterparts. Furthermore, in F78Ri plants, the endogenous levels of HPODEs and HODEs increased significantly, compared with wild-type plants. These results suggest that the increased accumulation of antifungal oxylipins, such as HPODEs and HODEs, causes the enhancement of disease resistance against M. grisea.

AB - Linoleic acid (18:2) and linolenic acid (18:3) are sources for various oxidized metabolites called oxylipins, some of which inhibit growth of fungal pathogens. In a previous study, we found disease resistance to rice blast fungus Magnaporthe grisea enhanced in 18:2-accumulating transgenic rice (F78Ri) in which the conversion from 18:2 to 18:3 was suppressed. Here, we demonstrate that 18:2-derived hydroperoxides and hydroxides (HPODEs and HODEs, respectively) inhibit growth of M. grisea more strongly than their 18:3-derived counterparts. Furthermore, in F78Ri plants, the endogenous levels of HPODEs and HODEs increased significantly, compared with wild-type plants. These results suggest that the increased accumulation of antifungal oxylipins, such as HPODEs and HODEs, causes the enhancement of disease resistance against M. grisea.

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Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid

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