Endothelin-1-induced prostaglandin E2 production: modulation of contractile response to endothelin-1 in porcine coronary artery

Satoshi Suzuki; Akito Suzuki; Junko Kajikuri; Takeo Itoh

doi:10.1016/0014-2999(92)90517-8

Endothelin-1-induced prostaglandin E₂ production: modulation of contractile response to endothelin-1 in porcine coronary artery

Satoshi Suzuki
, Akito Suzuki
, Junko Kajikuri
, Takeo Itoh

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Endothelin-1 (ET-1, 1 nM) increased the release of prostaglandin E₂ (PGE₂) in endothelium-denuded smooth muscle strips of porcine coronary arteries. Indomethacin enhanced the amplitude of contraction induced by ET-1 and inhibited the stimulated release of PGE₂. PGE₂ (0.1-100 nM) attenuated the amplitude of contraction induced by 1 nM ET-1. These results suggest that in the smooth muscle of porcine coronary arteries, ET-1 increased the synthesis of PGE₂, which functionally antagonizes the direct vasoconstrictor actions of ET-1.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	European Journal of Pharmacology
Volume	217
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(92)90517-8
Publication status	Published - Jun 24 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0014-2999(92)90517-8

Cite this

@article{17241e074b7a4d60acd743b295288181,

title = "Endothelin-1-induced prostaglandin E2 production: modulation of contractile response to endothelin-1 in porcine coronary artery",

abstract = "Endothelin-1 (ET-1, 1 nM) increased the release of prostaglandin E2 (PGE2) in endothelium-denuded smooth muscle strips of porcine coronary arteries. Indomethacin enhanced the amplitude of contraction induced by ET-1 and inhibited the stimulated release of PGE2. PGE2 (0.1-100 nM) attenuated the amplitude of contraction induced by 1 nM ET-1. These results suggest that in the smooth muscle of porcine coronary arteries, ET-1 increased the synthesis of PGE2, which functionally antagonizes the direct vasoconstrictor actions of ET-1.",

keywords = "Coronary artery (porcine), Endothelin-1, Prostaglandin E, Smooth muscle (vascular)",

author = "Satoshi Suzuki and Akito Suzuki and Junko Kajikuri and Takeo Itoh",

note = "Funding Information: We are grateful to Prof. H. Kuriyama for his advice and to Dr. A.H. Weston (University of Manchester) for critical reading of the manuscript. This work was partly supported by a Grant-in-Aid from the Ministry of Education of Japan, the Ichiro Kanehara Foundation and the Japan Heart Foundation.",

year = "1992",

month = jun,

day = "24",

doi = "10.1016/0014-2999(92)90517-8",

language = "English",

volume = "217",

pages = "97--100",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Endothelin-1-induced prostaglandin E2 production

T2 - modulation of contractile response to endothelin-1 in porcine coronary artery

AU - Suzuki, Satoshi

AU - Suzuki, Akito

AU - Kajikuri, Junko

AU - Itoh, Takeo

N1 - Funding Information: We are grateful to Prof. H. Kuriyama for his advice and to Dr. A.H. Weston (University of Manchester) for critical reading of the manuscript. This work was partly supported by a Grant-in-Aid from the Ministry of Education of Japan, the Ichiro Kanehara Foundation and the Japan Heart Foundation.

PY - 1992/6/24

Y1 - 1992/6/24

N2 - Endothelin-1 (ET-1, 1 nM) increased the release of prostaglandin E2 (PGE2) in endothelium-denuded smooth muscle strips of porcine coronary arteries. Indomethacin enhanced the amplitude of contraction induced by ET-1 and inhibited the stimulated release of PGE2. PGE2 (0.1-100 nM) attenuated the amplitude of contraction induced by 1 nM ET-1. These results suggest that in the smooth muscle of porcine coronary arteries, ET-1 increased the synthesis of PGE2, which functionally antagonizes the direct vasoconstrictor actions of ET-1.

AB - Endothelin-1 (ET-1, 1 nM) increased the release of prostaglandin E2 (PGE2) in endothelium-denuded smooth muscle strips of porcine coronary arteries. Indomethacin enhanced the amplitude of contraction induced by ET-1 and inhibited the stimulated release of PGE2. PGE2 (0.1-100 nM) attenuated the amplitude of contraction induced by 1 nM ET-1. These results suggest that in the smooth muscle of porcine coronary arteries, ET-1 increased the synthesis of PGE2, which functionally antagonizes the direct vasoconstrictor actions of ET-1.

KW - Coronary artery (porcine)

KW - Endothelin-1

KW - Prostaglandin E

KW - Smooth muscle (vascular)

UR - https://www.scopus.com/pages/publications/0026724451

UR - https://www.scopus.com/pages/publications/0026724451#tab=citedBy

U2 - 10.1016/0014-2999(92)90517-8

DO - 10.1016/0014-2999(92)90517-8

M3 - Article

C2 - 1397025

AN - SCOPUS:0026724451

SN - 0014-2999

VL - 217

SP - 97

EP - 100

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Endothelin-1-induced prostaglandin E₂ production: modulation of contractile response to endothelin-1 in porcine coronary artery

Abstract

All Science Journal Classification (ASJC) codes

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