Endometrial carcinoma associated with hyperplasia

Tsunehisa Kaku, Naoki Tsukamoto, Tooru Hachisuga, Nobuhiro Tsuruchi, Kunihiro Sakai, Toshio Hirakawa, Satoshi Amada, Toshiaki Saito, Toshiharu Kamura, Hitoo Nakano

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


The aim of this study was to clarify the relationship of endometrial hyperplasia to endometrial carcinoma. From 1979 through 1990, 115 cases of stage I-IV endometrial carcinomas treated initially by hysterectomy were reviewed histologically. Forty-two of 115 (36.5%) patients had hyperplasia in the endometrium adjacent to the carcinoma. Women with both endometrial carcinoma and hyperplasia were significantly younger than those with carcinoma without hyperplasia (P < 0.05). In a comparison of patients with carcinoma without hyperplasia, those with hyperplasia were better differentiated (P = 0.0072), and lacked deep myometrial invasion (P < 0.0001), cervical involvement (P = 0.0192), lymph-vascular space invasion (P = 0.0102), and para-aortic lymph node metastase (P = 0.0434). The presence of hyperplasia was also significantly correlated with the presence of endometrial metaplasia (P = 0.0001). The estimated 5-year survival rates for patients with carcinoma with hyperplasia and those with carcinoma without hyperplasia were 96.55 and 73.33%, respectively (P = 0.0016). In endometrial carcinomas, the presence of endometrial hyperplasia may demonstrate a more favorable prognosis.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalGynecologic Oncology
Issue number1
Publication statusPublished - Jan 1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology


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