Endocrine disruptors and nuclear receptors

Hajime Watanabe, Taisen Iguchi, Ken ichiro Morohashi

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Endocrine dirsuptors are supposed to modulate function of nuclear receptors by binding their ligand-binding domain. As nuclear receptors are ligand dependent transcription factor, endocrine disruptors function as agonist or antagonist. Although actual mechanism of endocrine disruption is not well understood, several nuclear receptors are reported as targets of endocrine disruptors. In this review, the functions of nuclear receptors suspected as targets of endocrine disruptors are described.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number2
Publication statusPublished - Feb 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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