TY - JOUR
T1 - End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug
T2 - Torpedo-Shaped Peptidic Nanocapsules
AU - Ueda, Motoki
AU - Seo, Siyoong
AU - Nair, Baiju G.
AU - Müller, Stefan
AU - Takahashi, Eiki
AU - Arai, Takashi
AU - Iyoda, Tomonori
AU - Fujii, Shin Ichiro
AU - Tsuneda, Satoshi
AU - Ito, Yoshihiro
N1 - Funding Information:
This work was financially supported by the Japan Society for the Promotion of Science as well as a Grant-in-Aid for Scientific Research (S) from KAKENHI 22220009 and a Grant-in-Aid for Scientific Research (A) from KAKENHI 15H01810. TEM measurements were supported by the Materials Characterization Support Unit, RIKEN CEMS. We thank Sarah Dodds, Ph.D., from Edanz Group (www. edanzediting.com/ac) for editing a draft of this manuscript.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/1/22
Y1 - 2019/1/22
N2 - Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.
AB - Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.
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U2 - 10.1021/acsnano.8b06189
DO - 10.1021/acsnano.8b06189
M3 - Article
C2 - 30606006
AN - SCOPUS:85059803858
SN - 1936-0851
VL - 13
SP - 305
EP - 312
JO - ACS nano
JF - ACS nano
IS - 1
ER -