Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation

Yayoi Matsuo; Kenjiro Kamezaki; Shoichiro Takeishi; Katsuto Takenaka; Tetsuya Eto; Atsushi Nonami; Toshihiro Miyamoto; Hiromi Iwasaki; Naoki Harada; Koji Nagafuji; Takanori Teshima; Koichi Akashi

doi:10.2169/internalmedicine.48.2003

Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation

Yayoi Matsuo, Kenjiro Kamezaki, Shoichiro Takeishi, Katsuto Takenaka, Tetsuya Eto, Atsushi Nonami, Toshihiro Miyamoto, Hiromi Iwasaki, Naoki Harada, Koji Nagafuji, Takanori Teshima, Koichi Akashi

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Abstract

We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplanation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.

Original language	English
Pages (from-to)	1453-1456
Number of pages	4
Journal	Internal Medicine
Volume	48
Issue number	16
DOIs	https://doi.org/10.2169/internalmedicine.48.2003
Publication status	Published - 2009

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.48.2003

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Matsuo, Y., Kamezaki, K., Takeishi, S., Takenaka, K., Eto, T., Nonami, A., Miyamoto, T., Iwasaki, H., Harada, N., Nagafuji, K., Teshima, T., & Akashi, K. (2009). Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation. Internal Medicine, 48(16), 1453-1456. https://doi.org/10.2169/internalmedicine.48.2003

Matsuo, Y, Kamezaki, K, Takeishi, S, Takenaka, K, Eto, T, Nonami, A, Miyamoto, T, Iwasaki, H, Harada, N, Nagafuji, K, Teshima, T & Akashi, K 2009, 'Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation', Internal Medicine, vol. 48, no. 16, pp. 1453-1456. https://doi.org/10.2169/internalmedicine.48.2003

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abstract = "We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplanation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.",

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AU - Matsuo, Yayoi

AU - Kamezaki, Kenjiro

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AU - Takenaka, Katsuto

AU - Eto, Tetsuya

AU - Nonami, Atsushi

AU - Miyamoto, Toshihiro

AU - Iwasaki, Hiromi

AU - Harada, Naoki

AU - Nagafuji, Koji

AU - Teshima, Takanori

AU - Akashi, Koichi

PY - 2009

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AB - We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplanation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.

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Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation

Abstract

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