Enantioselective synthesis of silanol

Kazunobu Igawa, Junko Takada, Tomohiro Shimono, Katsuhiko Tomooka

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


An enantioselective nucleophilic substitution reaction of achiral dialkoxysilane has been developed. The reaction proceeds with efficient stereocontrol on the silicon chirality center to give the enantioenriched silyl ether, which can be converted to the silanol without loss of enantiopurity. We have analyzed the steric course of the reaction by using DFT calculations and propose a transition state model to explain the observed enantioselectivity.

Original languageEnglish
Pages (from-to)16132-16133
Number of pages2
JournalJournal of the American Chemical Society
Issue number48
Publication statusPublished - Dec 3 2008

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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