Enantioselective Synthesis of Silacyclopentanes

Kazunobu Igawa, Daisuke Yoshihiro, Yusuke Abe, Katsuhiko Tomooka

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.

Original languageEnglish
Pages (from-to)5814-5818
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number19
Publication statusPublished - May 4 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)


Dive into the research topics of 'Enantioselective Synthesis of Silacyclopentanes'. Together they form a unique fingerprint.

Cite this