Enantio- and regioselective intermolecular benzylic and allylic C-H bond amination

Yota Nishioka; Tatsuya Uchida; Tsutomu Katsuki

doi:10.1002/anie.201208906

Enantio- and regioselective intermolecular benzylic and allylic C-H bond amination

Yota Nishioka, Tatsuya Uchida, Tsutomu Katsuki

Division for Experimental Natural Science

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

Smooth salen: Ru(CO)-salen complex 1 is an effective catalyst for asymmetric benzylic and allylic C-H bond amination using 2-(trimethylsilyl) ethanesulfonyl azide (SESN₃) as the nitrene source. The reaction proceeded with high enantioselectivity and excellent regioselectivity. An ethyl group can be selectively aminated, even in the presence of an n-propyl group. No migration or isomerization of the double bond was observed.

Original language	English
Pages (from-to)	1739-1742
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	6
DOIs	https://doi.org/10.1002/anie.201208906
Publication status	Published - Feb 4 2013

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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10.1002/anie.201208906

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abstract = "Smooth salen: Ru(CO)-salen complex 1 is an effective catalyst for asymmetric benzylic and allylic C-H bond amination using 2-(trimethylsilyl) ethanesulfonyl azide (SESN3) as the nitrene source. The reaction proceeded with high enantioselectivity and excellent regioselectivity. An ethyl group can be selectively aminated, even in the presence of an n-propyl group. No migration or isomerization of the double bond was observed.",

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AU - Katsuki, Tsutomu

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Enantio- and regioselective intermolecular benzylic and allylic C-H bond amination

Abstract

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