Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis

M. Furue; K. Yamamura; M. Kido-Nakahara; T. Nakahara; Y. Fukui

doi:10.1111/all.13239

Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis

M. Furue, K. Yamamura, M. Kido-Nakahara, T. Nakahara, Y. Fukui

Research output: Contribution to journal › Review article › peer-review

182 Citations (Scopus)

Abstract

Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (T_H2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from T_H2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.

Original language	English
Pages (from-to)	29-36
Number of pages	8
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	73
Issue number	1
DOIs	https://doi.org/10.1111/all.13239
Publication status	Published - Jan 2018

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1111/all.13239

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title = "Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis",

abstract = "Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.",

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AU - Nakahara, T.

AU - Fukui, Y.

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N2 - Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.

AB - Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.

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Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis

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