TY - JOUR
T1 - Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis
AU - Inoue, Hirofumi
AU - Matsushige, Takeshi
AU - Ichiyama, Takashi
AU - Okuno, Alato
AU - Takikawa, Osamu
AU - Tomonaga, Shozo
AU - Anlar, Banu
AU - Yüksel, Deniz
AU - Otsuka, Yasushi
AU - Kohno, Fumitaka
AU - Hoshide, Madoka
AU - Ohga, Shouichi
AU - Hasegawa, Shunji
N1 - Funding Information:
This work was supported by grants from the Ministry of Health, Labor and Welfare (the Research Committee of Prion Disease and Slow Virus Infection) of Japan and by JSPS KAKENHI Grant Number JP15K09654 .
Publisher Copyright:
© 2019
PY - 2020/2/15
Y1 - 2020/2/15
N2 - Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.
AB - Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.
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U2 - 10.1016/j.jneuroim.2019.577088
DO - 10.1016/j.jneuroim.2019.577088
M3 - Article
C2 - 31733567
AN - SCOPUS:85074724177
SN - 0165-5728
VL - 339
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577088
ER -
