Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice

Fujio Umehara, Kenichi Mishima, Nobuaki Egashira, Ayumi Ogata, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


To investigate the functional role of Desert hedgehog (Dhh) gene in the nervous system, we examined motor, sensory, learning and memory functions as well as mood in Dhh knockout (KO) mice. Dhh KO male mice exhibited prolonged immobility time compared with wild-type male mice in the forced swimming test, and showed enhanced inhibition in the Vogel's conflict model. These findings suggest that Dhh KO male mice exhibited enhanced anxiety and depressive behavior compared with wild-type male mice. In contrast, Dhh KO female mice did not show any significant difference compared to wild-type female mice. These behavioral abnormalities of Dhh KO male mice may be due to lower testosterone levels with abnormal development of the testes caused by Dhh-null mutation.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - Nov 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience


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