Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases

Yoshio Hayashi; Thomas Regnier; Shigenobu Nishiguchi; Magne O. Sydnes; Daisuke Hashimoto; Junya Hasegawa; Takahiro Katoh; Tetsuya Kajimoto; Masataka Shiozuka; Ryoichi Matsuda; Manabu Node; Yoshiaki Kiso

doi:10.1039/b801498a

Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases

Yoshio Hayashi, Thomas Regnier, Shigenobu Nishiguchi, Magne O. Sydnes, Daisuke Hashimoto, Junya Hasegawa, Takahiro Katoh, Tetsuya Kajimoto, Masataka Shiozuka, Ryoichi Matsuda, Manabu Node, Yoshiaki Kiso

Center for Clinical and Translational Research(CCTR)

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.

Original language	English
Pages (from-to)	2379-2381
Number of pages	3
Journal	Chemical Communications
Issue number	20
DOIs	https://doi.org/10.1039/b801498a
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b801498a

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title = "Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases",

abstract = "Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.",

author = "Yoshio Hayashi and Thomas Regnier and Shigenobu Nishiguchi and Sydnes, {Magne O.} and Daisuke Hashimoto and Junya Hasegawa and Takahiro Katoh and Tetsuya Kajimoto and Masataka Shiozuka and Ryoichi Matsuda and Manabu Node and Yoshiaki Kiso",

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T1 - Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases

AU - Hayashi, Yoshio

AU - Regnier, Thomas

AU - Nishiguchi, Shigenobu

AU - Sydnes, Magne O.

AU - Hashimoto, Daisuke

AU - Hasegawa, Junya

AU - Katoh, Takahiro

AU - Kajimoto, Tetsuya

AU - Shiozuka, Masataka

AU - Matsuda, Ryoichi

AU - Node, Manabu

AU - Kiso, Yoshiaki

PY - 2008

Y1 - 2008

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ER -

Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases

Abstract

All Science Journal Classification (ASJC) codes

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