Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex

Yasufumi Fuchi; Shigeki Sasaki

doi:10.1021/ol500452r

Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex

Yasufumi Fuchi, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A novel 1,3-diazaphenoxazine nucleoside derivative (nitroG-Grasp) bearing a thiol group with a urea linker forms multiple hydrogen-bonded complexes with 8-nitroguanosine and efficiently displaces the nitro group; thus, it is the first molecule that can covalently capture 8-nitroguanosine.

Original language	English
Pages (from-to)	1760-1763
Number of pages	4
Journal	Organic letters
Volume	16
Issue number	6
DOIs	https://doi.org/10.1021/ol500452r
Publication status	Published - Mar 21 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol500452r

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abstract = "A novel 1,3-diazaphenoxazine nucleoside derivative (nitroG-Grasp) bearing a thiol group with a urea linker forms multiple hydrogen-bonded complexes with 8-nitroguanosine and efficiently displaces the nitro group; thus, it is the first molecule that can covalently capture 8-nitroguanosine.",

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Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex

Abstract

All Science Journal Classification (ASJC) codes

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