Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine

Yo ichi Yamashita, Takanobu Yamao, Yosuke Nakao, Tatsunori Miyata, Yasuhiro Ikegami, Soichiro Yamane, Taiga Ito, Taku Furukawa, Jaeyong Cho, Fanqi Wu, Yasumitsu Fujie, Mitsuru Arima, Shinichi Aishima, Hiroyuki Ijima, Hideo Baba

Research output: Contribution to journalArticlepeer-review


Purpose: At present, ≥ 20% of patients experience clinically relevant postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). Methods: We developed a new bioabsorbable pancreatic clip (BioPaC) made of polycaprolactone that does not crush the pancreatic parenchyma during occlusion of the pancreatic stump. We confirmed the efficacy of this BioPac in a porcine DP model and compared it to a linear stapling device (Reinforce®). Results: Pigs were killed at 1 month after DP. In the BioPaC group, all swine (n = 3) survived well without POPF. In the Reinforce® group (n = 2), one pig died early at postoperative day 7 with Grade C POPF (amylase 43 700 U/l), and the other survived until 1 month at scarification with biochemical leakage of POPF (amylase 3 725 U/l). Pathologically, the main pancreatic duct and pancreatic parenchyma were well closed by BioPaC. Conclusion: The newly developed BioPaC is effective in a porcine DP model.

Original languageEnglish
Pages (from-to)1109-1114
Number of pages6
JournalSurgery today
Issue number7
Publication statusPublished - Jul 2022

All Science Journal Classification (ASJC) codes

  • Surgery


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