TY - JOUR
T1 - Effects of Thai Musa species on prevention of UVB-induced skin damage in mice
AU - Viyoch, Jarupa
AU - Mahingsa, Khuanrudee
AU - Ingkaninan, Kornkanok
N1 - Funding Information:
Financial support for this study came from Thailand Research Fund (TRF). The authors would like to acknowledge Faculty of Pharmaceutical Sciences, Naresuan University for their facility support. In addition, we also thank Dr. C. Norman Scholfield for his discussion.
PY - 2012/12
Y1 - 2012/12
N2 - The effects of oral administration of Musa sapientum and Musa suerier on prevention of UVB induced skin damages were investigated in male ICR mice. Animals were orally administered 50mg/day ascorbic acid, or M. sapientum or M. suerier's fruit pulps at dose of 0.5, 1 or 1.5mg/g body weight/day for 12weeks. Concurrently, the shaved backs of animals were irradiated with UVB for 12weeks. The intensity of irradiation was progressively increased, from 54mJ/cm2 per exposure at week 1-126mJ/cm2 at week 11. A significant decrease (p<0.05) in skin elasticity (from 0.82±0.02 to 0.42±0.09) and total glutathione (from (193.6±18.7 to 152.7±7.8ng/mg protein) as compared with the control group (water-administered UVB-irradiated mice) was observed after 12weeks of UVB exposure. When l-ascorbic acid (0.72±0.01) or 1mg/g body weight/day M. suerier (0.84±0.06) were administered to UVB-irradiated mice, the reduction in skin elasticity was significantly inhibited (p<0.05). Moreover, the significant increase (p<0.05) in level of total glutathione was found in these groups (220.8±13.3ng/mg protein for l-ascorbic acid and 224.9±20.1ng/mg protein for M. suerier). These findings suggest the potential effect of daily consumption of M. suerier on prevention of skin damage from repeated UVB exposure.
AB - The effects of oral administration of Musa sapientum and Musa suerier on prevention of UVB induced skin damages were investigated in male ICR mice. Animals were orally administered 50mg/day ascorbic acid, or M. sapientum or M. suerier's fruit pulps at dose of 0.5, 1 or 1.5mg/g body weight/day for 12weeks. Concurrently, the shaved backs of animals were irradiated with UVB for 12weeks. The intensity of irradiation was progressively increased, from 54mJ/cm2 per exposure at week 1-126mJ/cm2 at week 11. A significant decrease (p<0.05) in skin elasticity (from 0.82±0.02 to 0.42±0.09) and total glutathione (from (193.6±18.7 to 152.7±7.8ng/mg protein) as compared with the control group (water-administered UVB-irradiated mice) was observed after 12weeks of UVB exposure. When l-ascorbic acid (0.72±0.01) or 1mg/g body weight/day M. suerier (0.84±0.06) were administered to UVB-irradiated mice, the reduction in skin elasticity was significantly inhibited (p<0.05). Moreover, the significant increase (p<0.05) in level of total glutathione was found in these groups (220.8±13.3ng/mg protein for l-ascorbic acid and 224.9±20.1ng/mg protein for M. suerier). These findings suggest the potential effect of daily consumption of M. suerier on prevention of skin damage from repeated UVB exposure.
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U2 - 10.1016/j.fct.2012.08.060
DO - 10.1016/j.fct.2012.08.060
M3 - Article
C2 - 22986089
AN - SCOPUS:84867059003
SN - 0278-6915
VL - 50
SP - 4292
EP - 4301
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 12
ER -