Effects of sodium β-sitosteryl sulfate on the phase behavior of dipalmitoylphosphatidylcholine

Ananda Kafle, Takeshi Misono, Avinash Bhadani, Kenichi Sakai, Chihiro Kaise, Teruhisa Kaneko, Hideki Sakai

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


We have studied the phase behavior of dipalmitoylphosphatidylcholine (DPPC) containing sodium β-sitosteryl sulfate (PSO4). PSO4 was found to lower the phase transition temperature of DPPC to a higher degree than cholesterol or β-sitosterol. It also gave rise to the formation of a modulated (ripple) phase (Pβ) at low to moderate concentrations. At concentrations greater than 25 mol%, it completely changed the membrane into a fluid phase. This shows that PSO4 is capable of disordering the hydrocarbon chains of PC efficiently. The characteristics of PSO4 for fluidizing the membrane can be useful for the pharmaceutical and cosmetics industries.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Publication statusPublished - Jan 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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