Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro

Y. Nakashima; W. J. Maloney; S. B. Goodman; D. H. Sun; D. J. Schurman; R. L. Smith

Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro

Y. Nakashima, W. J. Maloney, S. B. Goodman, D. H. Sun, D. J. Schurman, R. L. Smith

Research output: Contribution to conference › Paper › peer-review

Abstract

The effects of metallic debris and bone cement (PMMA) particles on the release of neural metalloproteinases from human macrophages in vitro are studied. Results demonstrated that both titanium alloy debris and PMMA particles induced MMP-9 in isolated macrophages. It is noted that MMP-9 is the predominant metalloproteinase from macrophages and MMP-2 is expressed only at higher particle concentrations. The results confirm the hypothesis that macrophages respond to particles by releasing matrix metalloproteinases.

Original language	English
Pages	856
Number of pages	1
Publication status	Published - 1996
Externally published	Yes
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

All Science Journal Classification (ASJC) codes

Materials Science(all)

Cite this

@conference{4b5270cd8f9f48898cab9b6b83ace0e7,

title = "Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro",

abstract = "The effects of metallic debris and bone cement (PMMA) particles on the release of neural metalloproteinases from human macrophages in vitro are studied. Results demonstrated that both titanium alloy debris and PMMA particles induced MMP-9 in isolated macrophages. It is noted that MMP-9 is the predominant metalloproteinase from macrophages and MMP-2 is expressed only at higher particle concentrations. The results confirm the hypothesis that macrophages respond to particles by releasing matrix metalloproteinases.",

author = "Y. Nakashima and Maloney, {W. J.} and Goodman, {S. B.} and Sun, {D. H.} and Schurman, {D. J.} and Smith, {R. L.}",

year = "1996",

language = "English",

pages = "856",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

}

TY - CONF

T1 - Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro

AU - Nakashima, Y.

AU - Maloney, W. J.

AU - Goodman, S. B.

AU - Sun, D. H.

AU - Schurman, D. J.

AU - Smith, R. L.

PY - 1996

Y1 - 1996

N2 - The effects of metallic debris and bone cement (PMMA) particles on the release of neural metalloproteinases from human macrophages in vitro are studied. Results demonstrated that both titanium alloy debris and PMMA particles induced MMP-9 in isolated macrophages. It is noted that MMP-9 is the predominant metalloproteinase from macrophages and MMP-2 is expressed only at higher particle concentrations. The results confirm the hypothesis that macrophages respond to particles by releasing matrix metalloproteinases.

AB - The effects of metallic debris and bone cement (PMMA) particles on the release of neural metalloproteinases from human macrophages in vitro are studied. Results demonstrated that both titanium alloy debris and PMMA particles induced MMP-9 in isolated macrophages. It is noted that MMP-9 is the predominant metalloproteinase from macrophages and MMP-2 is expressed only at higher particle concentrations. The results confirm the hypothesis that macrophages respond to particles by releasing matrix metalloproteinases.

UR - http://www.scopus.com/inward/record.url?scp=0030403744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030403744&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:0030403744

SP - 856

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro

Abstract

Other

All Science Journal Classification (ASJC) codes

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