Effects of osteoblast-like cell seeding on the mechanical properties of porous composite scaffolds

Takaaki Arahira, Mitsugu Todo

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    In tissue engineering technology, polymer-ceramics or polymer-polymer composites have been considered as advanced scaffolds having mechanical stability, biocompatibility, cell proliferation, and easy processability. However, the relationship between the mechanical properties and the cell proliferation behavior of such composite scaffolds has not been clarified yet. In this study, two types of composite scaffolds, poly(ethylene terephthalate) (PET) fiber/collagen and β-tricalcium phosphate (β-TCP)/gelatin scaffolds, were investigated. MC3T3-E1 cells were cultured in these scaffolds under appropriate conditions. Compression tests were then periodically conducted to evaluate the compressive elastic modulus. It was found that the modulus of the scaffolds containing cells increased with the cell culture period. It is noted that the modulus of the β-TCP/gelatin with cells was approximately seven times larger than that of the PET fiber/collagen with cells.

    Original languageEnglish
    Pages (from-to)79-90
    Number of pages12
    JournalAdvanced Composite Materials
    Volume24
    DOIs
    Publication statusPublished - Dec 31 2015

    All Science Journal Classification (ASJC) codes

    • Ceramics and Composites
    • Mechanics of Materials
    • Mechanical Engineering

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