TY - JOUR
T1 - Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats
AU - Liu, Lin
AU - Igarashi, Kaoru
AU - Haruyama, Naoto
AU - Saeki, Shuichi
AU - Shinoda, Hisashi
AU - Mitani, Hideo
N1 - Funding Information:
We wish to thank Dr M. Ohtsuka-Isoya for her valuable advice. This research was supported in part by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Sports, and Culture of Japan (no. 13672138).
PY - 2004
Y1 - 2004
N2 - Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-week-old male Wistar rats were moved buccally with a standardized expansion spring. Clodronate solution was injected into the sub-periosteum area adjacent to the left upper molar every third day during the experimental period. The right first molar served as the control. Local injection of clodronate caused a significant (P < 0.001) and dose-dependent reduction in tooth movement in the rats. The number of osteoclasts on the clodronate-injected side was significantly less (P < 0.01) than on the control side. Local clodronate also inhibited root resorption incident to tooth movement. These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment.
AB - Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-week-old male Wistar rats were moved buccally with a standardized expansion spring. Clodronate solution was injected into the sub-periosteum area adjacent to the left upper molar every third day during the experimental period. The right first molar served as the control. Local injection of clodronate caused a significant (P < 0.001) and dose-dependent reduction in tooth movement in the rats. The number of osteoclasts on the clodronate-injected side was significantly less (P < 0.01) than on the control side. Local clodronate also inhibited root resorption incident to tooth movement. These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment.
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U2 - 10.1093/ejo/26.5.469
DO - 10.1093/ejo/26.5.469
M3 - Article
C2 - 15536834
AN - SCOPUS:16644368865
SN - 0141-5387
VL - 26
SP - 469
EP - 473
JO - European Journal of Orthodontics
JF - European Journal of Orthodontics
IS - 5
ER -