TY - JOUR
T1 - Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus
AU - Ito, Isao
AU - Hidaka, Hiroyoshi
AU - Sugiyama, Hiroyuki
PY - 1991/1/2
Y1 - 1991/1/2
N2 - Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-l-tyrosyl-4-phenylpiperazine), a specific inhibitor of calcium/calmodulin-dependent protein kinase II, were examined using rat hippocampus slices in vitro. The inhibitor, when applied in bathing solutions prior to and present during the tetanic stimulations, blocked the generation of long-term potentiation (LTP) in CA1 regions without affecting basal synaptic transmission itself, suggesting an important role of this kinase in the molecular mechanism of CA1 LTP. In contrast, mossy fiber LTP in CA3 regions was not affected significantly by the inhibitor.
AB - Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-l-tyrosyl-4-phenylpiperazine), a specific inhibitor of calcium/calmodulin-dependent protein kinase II, were examined using rat hippocampus slices in vitro. The inhibitor, when applied in bathing solutions prior to and present during the tetanic stimulations, blocked the generation of long-term potentiation (LTP) in CA1 regions without affecting basal synaptic transmission itself, suggesting an important role of this kinase in the molecular mechanism of CA1 LTP. In contrast, mossy fiber LTP in CA3 regions was not affected significantly by the inhibitor.
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U2 - 10.1016/0304-3940(91)90663-E
DO - 10.1016/0304-3940(91)90663-E
M3 - Article
C2 - 1850502
AN - SCOPUS:0026078933
SN - 0304-3940
VL - 121
SP - 119
EP - 121
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -