TY - JOUR
T1 - Effects of isolated compound from Sonneratia caseolaris leaf
T2 - A validation of traditional utilization by melanin biosynthesis and antioxidant assays
AU - Arung, Enos Tangke
AU - Kuspradini, Harlinda
AU - Kusuma, Irawan Wijaya
AU - Bang, Tran Hai
AU - Yamashita, Shuntaro
AU - Katakura, Yoshinori
AU - Shimizu, Kuniyoshi
N1 - Publisher Copyright:
© 2015 Enos Tangke Arung et al.
PY - 2015
Y1 - 2015
N2 - In continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O-?-glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O-?-glucoside showed the inhibitory activity in a dose-dependent manner and reach 44% of inhibition at 223.2 μM with 92% of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.
AB - In continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O-?-glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O-?-glucoside showed the inhibitory activity in a dose-dependent manner and reach 44% of inhibition at 223.2 μM with 92% of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.
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U2 - 10.7324/JAPS.2015.501007
DO - 10.7324/JAPS.2015.501007
M3 - Article
AN - SCOPUS:84946028069
SN - 2231-3354
VL - 5
SP - 39
EP - 43
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 10
ER -