TY - JOUR
T1 - Effects of Immunization of Mothers on the Immune Reaction of Their Offspring
T2 - Inhibition of Immune Responses of Offspring Caused by Antibody Imported Through the Milk
AU - IZUCHI, KUNIO
AU - TANIGUCHI, KAZUTO
AU - GONDO, HISASHI
AU - KAWAUCHI, HIDEYUKI
AU - KUBO, CHIHARU
AU - SHIRAKAWA, KOUICHI
AU - NOMOTO, KIKUO
PY - 1984/3
Y1 - 1984/3
N2 - ABSTRACT: Effects of immunization of pregnant AKR mice with nucleated chicken erythrocytes (CRBC) on immune responses of their offspring were examined. Antigen‐specific reduction of generation of cytotoxicity and plaque forming cells (PFC) was demonstrated in the offspring at 8 weeks after birth, and lasted for 15 weeks. Cross‐fostering experiments and cell transfer experiments showed that such suppression would be induced by antibody contained in the milk of immunized mothers rather than suppressor cells. Activities to enhance opsonization and to mediate antibody‐dependent cell‐mediated cytotoxicity (AI)CC) were demonstrated in the serum of such offspring before challenge with CRBC. Delayed footpad reaction (DFR) was maintained at the normal level in such offspring of immunized mice. 1984 Munksgaard
AB - ABSTRACT: Effects of immunization of pregnant AKR mice with nucleated chicken erythrocytes (CRBC) on immune responses of their offspring were examined. Antigen‐specific reduction of generation of cytotoxicity and plaque forming cells (PFC) was demonstrated in the offspring at 8 weeks after birth, and lasted for 15 weeks. Cross‐fostering experiments and cell transfer experiments showed that such suppression would be induced by antibody contained in the milk of immunized mothers rather than suppressor cells. Activities to enhance opsonization and to mediate antibody‐dependent cell‐mediated cytotoxicity (AI)CC) were demonstrated in the serum of such offspring before challenge with CRBC. Delayed footpad reaction (DFR) was maintained at the normal level in such offspring of immunized mice. 1984 Munksgaard
UR - http://www.scopus.com/inward/record.url?scp=0021248076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021248076&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.1984.tb00291.x
DO - 10.1111/j.1600-0897.1984.tb00291.x
M3 - Article
C2 - 6721030
AN - SCOPUS:0021248076
SN - 0271-7352
VL - 5
SP - 66
EP - 71
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 2
ER -