TY - JOUR
T1 - Effects of endoscopic injection sclerotherapy on portal hypertensive gastropathy
T2 - a prospective study
AU - Tanoue, Kazuo
AU - Hashizume, Makoto
AU - Wada, Hiroya
AU - Ohta, Masayuki
AU - Kitano, Seigo
AU - Sugimachi, Keizo
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for General Scientific Research 02807122 from the Ministry of Education, Science, and Culture, Japan. The authors are grateful for the assistance of M. Ohara.
PY - 1992
Y1 - 1992
N2 - The effect of endoscopic injection sclerotherapy (EIS) for esophageal varices on portal hypertensive gastropathy (PHG) was investigated in 137 patients who underwent EIS from July 1987 to March 1990. Two groups, PHG(+) (N = 35) and PHG(−) (N = 102) were distinguished by endoscopic findings obtained before EIS. PHG was classified into four grades by endoscopy scored as 0, 1, 2, or 3. The PHG score significantly worsened after EIS (p < 0.01), and PHG became worse 6 to 9 months after the eradication of varices followed by gradual improvement. Recurrent small veins, which required additional EIS, appeared more frequently in the PHG(+) group (p < 0.05). New gastric varices appeared or gastric varices enlarged after EIS more frequently in the PHG(+) group (7 patients, 20.0%) than in the PHG(−) group (12 patients, 11.8%), but this was not statistically significant. Thus, frequent endoscopy after EIS is needed with special attention directed to development of PHG and gastric varices, especially for patients with PHG prior to treatment.
AB - The effect of endoscopic injection sclerotherapy (EIS) for esophageal varices on portal hypertensive gastropathy (PHG) was investigated in 137 patients who underwent EIS from July 1987 to March 1990. Two groups, PHG(+) (N = 35) and PHG(−) (N = 102) were distinguished by endoscopic findings obtained before EIS. PHG was classified into four grades by endoscopy scored as 0, 1, 2, or 3. The PHG score significantly worsened after EIS (p < 0.01), and PHG became worse 6 to 9 months after the eradication of varices followed by gradual improvement. Recurrent small veins, which required additional EIS, appeared more frequently in the PHG(+) group (p < 0.05). New gastric varices appeared or gastric varices enlarged after EIS more frequently in the PHG(+) group (7 patients, 20.0%) than in the PHG(−) group (12 patients, 11.8%), but this was not statistically significant. Thus, frequent endoscopy after EIS is needed with special attention directed to development of PHG and gastric varices, especially for patients with PHG prior to treatment.
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U2 - 10.1016/S0016-5107(92)70522-7
DO - 10.1016/S0016-5107(92)70522-7
M3 - Article
C2 - 1397916
AN - SCOPUS:0026778617
SN - 0016-5107
VL - 38
SP - 582
EP - 585
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 5
ER -