Effects of dioxin-related compounds on bone mineral density in patients affected by the Yusho incident

Jun ichi Fukushi, Shoji Tokunaga, Yasuharu Nakashima, Goro Motomura, Chikage Mitoma, Hiroshi Uchi, Masutaka Furue, Yukihide Iwamoto

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Exposure to dioxin-related compounds results in many adverse health effects. Several studies have examined the effects of dioxin-related compounds on human bone metabolism with inconsistent results. In Japan in 1968, accidental human exposure to rice oil contaminated with dioxin-related compounds led to the development of Yusho oil disease. The aim of this study was to determine whether exposure to dioxin-related compounds was associated with bone mineral density in Yusho patients. In 2010, 262 women and 227 men underwent dual-energy X-ray absorptiometry bone scans as part of the nationwide Yusho health examination. Serum levels of polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls were measured using high-resolution gas chromatography and high-resolution mass spectrometry. When adjusted for prefecture, 1,2,3,4,7,8-HxCDD and 2,3,7,8-TCDF were significantly positively associated with Z-scores in men. No congeners were positively associated with Z-scores in women. After adjustment for prefecture and body mass index, one congener, 1,2,3,4,6,7,8-HpCDD, was negatively associated with Z-scores in women. In contrast, no congeners remained significant in men after adjusting for body mass index. This may suggest that 1,2,3,4,6,7,8-HpCDD has a negative effect on bone mineral density in women; however, the findings should be interpreted carefully, because no increase in the serum level of this congener was observed in patients with Yusho disease.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
Publication statusPublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • General Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Effects of dioxin-related compounds on bone mineral density in patients affected by the Yusho incident'. Together they form a unique fingerprint.

Cite this