Effects of carbonate ions in phosphate solution on the fabrication of carbonate apatite through a dissolution–precipitation reaction

Masaya Shimabukuro; Koichiro Hayashi; Ryo Kishida; Akira Tsuchiya; Kunio Ishikawa

doi:10.1016/j.ceramint.2021.09.188

Effects of carbonate ions in phosphate solution on the fabrication of carbonate apatite through a dissolution–precipitation reaction

Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

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Abstract

Carbonate apatite (CO₃Ap) artificial bone has attracted much attention due to its high osteoconductivity and replacement to bone. CO₃Ap is an inorganic component of bone, and has been fabricated by compositional transformation through a dissolution–precipitation reaction in Na₂HPO₄ solution using calcium carbonate as a precursor. In this study, the effects of the CO₃²⁻ concentration in the Na₂HPO₄ solution on the CO₃Ap fabrication reaction and the properties of the fabricated CO₃Ap were investigated. The rate of the compositional transformation became faster, and more CO₃ containing CO₃Ap was fabricated using CO₃²⁻ concentrated in Na₂HPO₄ solution. The crystal shape of CO₃Ap changed from scale-like to hexagonal crystals. In addition, the crystallite size increased with increasing CO₃²⁻ concentration in the Na₂HPO₄ solution. These changes lead to larger pores (≥0.02 μm) and decreased number of small pores (<0.02 μm) according to the CO₃ content in CO₃Ap, even though the total pore volume remained the same. These findings indicate that the CO₃²⁻ concentration in Na₂HPO₄ solution is an important factor for the CO₃Ap fabrication reaction and affects the properties of the fabricated CO₃Ap.

Original language	English
Pages (from-to)	1032-1037
Number of pages	6
Journal	Ceramics International
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/j.ceramint.2021.09.188
Publication status	Published - Jan 1 2022

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Process Chemistry and Technology
Surfaces, Coatings and Films
Materials Chemistry

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10.1016/j.ceramint.2021.09.188

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title = "Effects of carbonate ions in phosphate solution on the fabrication of carbonate apatite through a dissolution–precipitation reaction",

abstract = "Carbonate apatite (CO3Ap) artificial bone has attracted much attention due to its high osteoconductivity and replacement to bone. CO3Ap is an inorganic component of bone, and has been fabricated by compositional transformation through a dissolution–precipitation reaction in Na2HPO4 solution using calcium carbonate as a precursor. In this study, the effects of the CO32− concentration in the Na2HPO4 solution on the CO3Ap fabrication reaction and the properties of the fabricated CO3Ap were investigated. The rate of the compositional transformation became faster, and more CO3 containing CO3Ap was fabricated using CO32− concentrated in Na2HPO4 solution. The crystal shape of CO3Ap changed from scale-like to hexagonal crystals. In addition, the crystallite size increased with increasing CO32− concentration in the Na2HPO4 solution. These changes lead to larger pores (≥0.02 μm) and decreased number of small pores (<0.02 μm) according to the CO3 content in CO3Ap, even though the total pore volume remained the same. These findings indicate that the CO32− concentration in Na2HPO4 solution is an important factor for the CO3Ap fabrication reaction and affects the properties of the fabricated CO3Ap.",

author = "Masaya Shimabukuro and Koichiro Hayashi and Ryo Kishida and Akira Tsuchiya and Kunio Ishikawa",

note = "Funding Information: This study was supported in part by AMED under Grant Numbers JP21im0502004h and JSPS KAKENHI Grant Numbers JP20K23032 and JP21K18057 . Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd and Techna Group S.r.l.",

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AU - Shimabukuro, Masaya

AU - Hayashi, Koichiro

AU - Kishida, Ryo

AU - Tsuchiya, Akira

AU - Ishikawa, Kunio

N1 - Funding Information: This study was supported in part by AMED under Grant Numbers JP21im0502004h and JSPS KAKENHI Grant Numbers JP20K23032 and JP21K18057 . Publisher Copyright: © 2021 Elsevier Ltd and Techna Group S.r.l.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Carbonate apatite (CO3Ap) artificial bone has attracted much attention due to its high osteoconductivity and replacement to bone. CO3Ap is an inorganic component of bone, and has been fabricated by compositional transformation through a dissolution–precipitation reaction in Na2HPO4 solution using calcium carbonate as a precursor. In this study, the effects of the CO32− concentration in the Na2HPO4 solution on the CO3Ap fabrication reaction and the properties of the fabricated CO3Ap were investigated. The rate of the compositional transformation became faster, and more CO3 containing CO3Ap was fabricated using CO32− concentrated in Na2HPO4 solution. The crystal shape of CO3Ap changed from scale-like to hexagonal crystals. In addition, the crystallite size increased with increasing CO32− concentration in the Na2HPO4 solution. These changes lead to larger pores (≥0.02 μm) and decreased number of small pores (<0.02 μm) according to the CO3 content in CO3Ap, even though the total pore volume remained the same. These findings indicate that the CO32− concentration in Na2HPO4 solution is an important factor for the CO3Ap fabrication reaction and affects the properties of the fabricated CO3Ap.

AB - Carbonate apatite (CO3Ap) artificial bone has attracted much attention due to its high osteoconductivity and replacement to bone. CO3Ap is an inorganic component of bone, and has been fabricated by compositional transformation through a dissolution–precipitation reaction in Na2HPO4 solution using calcium carbonate as a precursor. In this study, the effects of the CO32− concentration in the Na2HPO4 solution on the CO3Ap fabrication reaction and the properties of the fabricated CO3Ap were investigated. The rate of the compositional transformation became faster, and more CO3 containing CO3Ap was fabricated using CO32− concentrated in Na2HPO4 solution. The crystal shape of CO3Ap changed from scale-like to hexagonal crystals. In addition, the crystallite size increased with increasing CO32− concentration in the Na2HPO4 solution. These changes lead to larger pores (≥0.02 μm) and decreased number of small pores (<0.02 μm) according to the CO3 content in CO3Ap, even though the total pore volume remained the same. These findings indicate that the CO32− concentration in Na2HPO4 solution is an important factor for the CO3Ap fabrication reaction and affects the properties of the fabricated CO3Ap.

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Effects of carbonate ions in phosphate solution on the fabrication of carbonate apatite through a dissolution–precipitation reaction

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