TY - JOUR
T1 - Effects of blood pump orientation on performance
T2 - In vitro assessment of universal advanced ventricular assist device
AU - Miyamoto, Takuma
AU - Kado, Yuichiro
AU - Polakowski, Anthony R.
AU - Horvath, David J.
AU - Kuban, Barry D.
AU - Fukamachi, Kiyotaka
AU - Karimov, Jamshid H.
N1 - Funding Information:
This program was supported by federal funding from the National Heart, Lung and Blood Institute under grant 5R21HL133871 (to K.F.).
Publisher Copyright:
© 2020 International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - An advanced ventricular assist device (VAD), which is under development in our institution, has specific features that allow changes in the axial rotor position and pump performance by intrapump pressure difference. However, performance could be influenced by the pump orientation because of the effect of gravity on the rotor position. The purpose of this study was to evaluate the effects of pump orientation on the pump performance, including pulse pressure and regurgitant flow through the pump when the pump was stopped. Bench testing of the VAD was performed on a static or pulsatile mock loop with a pneumatic device to simulate the native ventricle. The pump performance, including pressure–flow curve, pulsatility, and regurgitant flow, was evaluated at several angles, ranging from −90° (inlet pointed upward) to +90° (inlet pointed downward) at pump speeds of 2000, 2500, 3000, and 3500 rpm. The pump performance was slightly lower at +90° at all rotational speeds, compared with −90°. The pulse pressure on the pulsatile mock loop (80 bpm) was 50 mm Hg without pump support, remained at 50 mm Hg during pump support, and was not changed by orientation (−90°, 0°, and +90°). When the pump was stopped, the regurgitant flow was near 0 L/min at all angles. Pump orientation had a minor effect on pump performance, with no effect on pulse pressure or regurgitant flow when the pump was stopped. This indicates that the effect of gravity on the rotor assembly is insignificant.
AB - An advanced ventricular assist device (VAD), which is under development in our institution, has specific features that allow changes in the axial rotor position and pump performance by intrapump pressure difference. However, performance could be influenced by the pump orientation because of the effect of gravity on the rotor position. The purpose of this study was to evaluate the effects of pump orientation on the pump performance, including pulse pressure and regurgitant flow through the pump when the pump was stopped. Bench testing of the VAD was performed on a static or pulsatile mock loop with a pneumatic device to simulate the native ventricle. The pump performance, including pressure–flow curve, pulsatility, and regurgitant flow, was evaluated at several angles, ranging from −90° (inlet pointed upward) to +90° (inlet pointed downward) at pump speeds of 2000, 2500, 3000, and 3500 rpm. The pump performance was slightly lower at +90° at all rotational speeds, compared with −90°. The pulse pressure on the pulsatile mock loop (80 bpm) was 50 mm Hg without pump support, remained at 50 mm Hg during pump support, and was not changed by orientation (−90°, 0°, and +90°). When the pump was stopped, the regurgitant flow was near 0 L/min at all angles. Pump orientation had a minor effect on pump performance, with no effect on pulse pressure or regurgitant flow when the pump was stopped. This indicates that the effect of gravity on the rotor assembly is insignificant.
UR - http://www.scopus.com/inward/record.url?scp=85083690753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083690753&partnerID=8YFLogxK
U2 - 10.1111/aor.13690
DO - 10.1111/aor.13690
M3 - Article
C2 - 32239763
AN - SCOPUS:85083690753
SN - 0160-564X
VL - 44
SP - 1055
EP - 1060
JO - Artificial Organs
JF - Artificial Organs
IS - 10
ER -