TY - JOUR
T1 - Effects of β-sitosteryl sulfate on the properties of DPPC liposomes
AU - Kafle, Ananda
AU - Akamatsu, Masaaki
AU - Bhadani, Avinash
AU - Sakai, Kenichi
AU - Kaise, Chihiro
AU - Kaneko, Teruhisa
AU - Sakai, Hideki
N1 - Funding Information:
We are thankful to the Japan Government, Ministry of Education, Culture, Sports, Science and Technology (MEXT) for their scholarship grants (Monbukagakusho or MEXT scholarship). We would also like to thank Dr. Koji Tsuchiya for his assistance in electron microscopy.
Publisher Copyright:
© 2018 by Japan Oil Chemists’ Society.
PY - 2018
Y1 - 2018
N2 - The effect of β-sitosteryl sulfate (PSO4) on the liposomal size, stability, fluidity, and dispersibility of DPPC liposomes prepared by vortex mixing, bath-sonication, and probe-sonication has been studied. PSO4 significantly decreases the particle size of the multilamellar liposomes (MLVs). The sizes of the vortex-mixed and the bath-sonicated liposomes vary as a function of PSO4 concentration. On the other hand, PSO4 has only little effect on the particle sizes of probe sonicated liposomes. In some cases, the liposomal stability at higher PSO4 concentrations depends on the preparation method. PSO4 improves the dispersibility of the DPPC liposomes and enhances their hydration. It also increases the fluidity of the liposomes prepared by each method. Our results suggest that liposomes consisting of DPPC and PSO4 can be suitable as a cosmetic or pharmaceutical ingredient for the effective delivery of the active components into the body.
AB - The effect of β-sitosteryl sulfate (PSO4) on the liposomal size, stability, fluidity, and dispersibility of DPPC liposomes prepared by vortex mixing, bath-sonication, and probe-sonication has been studied. PSO4 significantly decreases the particle size of the multilamellar liposomes (MLVs). The sizes of the vortex-mixed and the bath-sonicated liposomes vary as a function of PSO4 concentration. On the other hand, PSO4 has only little effect on the particle sizes of probe sonicated liposomes. In some cases, the liposomal stability at higher PSO4 concentrations depends on the preparation method. PSO4 improves the dispersibility of the DPPC liposomes and enhances their hydration. It also increases the fluidity of the liposomes prepared by each method. Our results suggest that liposomes consisting of DPPC and PSO4 can be suitable as a cosmetic or pharmaceutical ingredient for the effective delivery of the active components into the body.
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U2 - 10.5650/jos.ess18147
DO - 10.5650/jos.ess18147
M3 - Article
C2 - 30429447
AN - SCOPUS:85058535522
SN - 1345-8957
VL - 67
SP - 1511
EP - 1519
JO - Journal of oleo science
JF - Journal of oleo science
IS - 12
ER -