Effects of β-sitosteryl sulfate on the properties of DPPC liposomes

Ananda Kafle, Masaaki Akamatsu, Avinash Bhadani, Kenichi Sakai, Chihiro Kaise, Teruhisa Kaneko, Hideki Sakai

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The effect of β-sitosteryl sulfate (PSO4) on the liposomal size, stability, fluidity, and dispersibility of DPPC liposomes prepared by vortex mixing, bath-sonication, and probe-sonication has been studied. PSO4 significantly decreases the particle size of the multilamellar liposomes (MLVs). The sizes of the vortex-mixed and the bath-sonicated liposomes vary as a function of PSO4 concentration. On the other hand, PSO4 has only little effect on the particle sizes of probe sonicated liposomes. In some cases, the liposomal stability at higher PSO4 concentrations depends on the preparation method. PSO4 improves the dispersibility of the DPPC liposomes and enhances their hydration. It also increases the fluidity of the liposomes prepared by each method. Our results suggest that liposomes consisting of DPPC and PSO4 can be suitable as a cosmetic or pharmaceutical ingredient for the effective delivery of the active components into the body.

Original languageEnglish
Pages (from-to)1511-1519
Number of pages9
JournalJournal of oleo science
Issue number12
Publication statusPublished - 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)


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