TY - JOUR
T1 - Effects of β-sitosteryl sulfate on the phase behavior and hydration properties of distearoylphosphatidylcholine
T2 - A comparison with dipalmitoylphosphatidylcholine
AU - Kafle, Ananda
AU - Misono, Takeshi
AU - Bhadani, Avinash
AU - Akamatsu, Masaaki
AU - Sakai, Kenichi
AU - Kaise, Chihiro
AU - Kaneko, Teruhisa
AU - Sakai, Hideki
N1 - Publisher Copyright:
© 2018 by Japan Oil Chemists’ Society.
PY - 2018
Y1 - 2018
N2 - We have studied the phase behavior of distearoylphosphatidylcholine (DSPC) in the presence of sodium β-sitosteryl sulfate (PSO4). PSO4 was found to induce sterol-rich and sterol-poor domains in the DSPC membrane. These two domains constitute a fluid, liquid ordered (Lo) phase and a gel (Lβ) phase. PSO4 was less miscible in DSPC than in a dipalmitoylphosphatidylcholine (DPPC) membrane, as evidenced by its tendency to separate from the bilayer at a concentration of 50 mol%. This lack of miscibility was attributed to the greater van der Waals forces between the PC hydrocarbon chains. In addition to affecting the phase behavior, PSO4 also enhanced the hydration of the membrane. Despite its weaker interaction with DSPC compared to DPPC, its tendency to fluidize this phospholipid and enhance its hydration can be useful in formulating cosmetics and pharmaceutical products.
AB - We have studied the phase behavior of distearoylphosphatidylcholine (DSPC) in the presence of sodium β-sitosteryl sulfate (PSO4). PSO4 was found to induce sterol-rich and sterol-poor domains in the DSPC membrane. These two domains constitute a fluid, liquid ordered (Lo) phase and a gel (Lβ) phase. PSO4 was less miscible in DSPC than in a dipalmitoylphosphatidylcholine (DPPC) membrane, as evidenced by its tendency to separate from the bilayer at a concentration of 50 mol%. This lack of miscibility was attributed to the greater van der Waals forces between the PC hydrocarbon chains. In addition to affecting the phase behavior, PSO4 also enhanced the hydration of the membrane. Despite its weaker interaction with DSPC compared to DPPC, its tendency to fluidize this phospholipid and enhance its hydration can be useful in formulating cosmetics and pharmaceutical products.
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U2 - 10.5650/jos.ess17182
DO - 10.5650/jos.ess17182
M3 - Article
C2 - 29526873
AN - SCOPUS:85044827547
SN - 1345-8957
VL - 67
SP - 433
EP - 443
JO - Journal of oleo science
JF - Journal of oleo science
IS - 4
ER -