Effects of β-sitosteryl sulfate on the hydration behavior of dipalmitoylphosphatidylcholine

Ananda Kafle; Takeshi Misono; Avinash Bhadani; Masaaki Akamatsu; Kenichi Sakai; Chihiro Kaise; Teruhisa Kaneko; Hideki Sakai

doi:10.5650/jos.ess17225

Effects of β-sitosteryl sulfate on the hydration behavior of dipalmitoylphosphatidylcholine

Ananda Kafle, Takeshi Misono, Avinash Bhadani, Masaaki Akamatsu, Kenichi Sakai, Chihiro Kaise, Teruhisa Kaneko, Hideki Sakai

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We investigated the hydration behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers containing sodium β-sitosteryl sulfate (PSO₄). PSO₄ was found to enhance hydration in the headgroup region of DPPC bilayers. Therefore, with the incorporation of PSO₄ into DPPC membranes, the amount of water required to reach the fully hydrated state was enhanced as indicated by the constant values of the main phase transition temperature (T_m) and the bilayer repeat distance (d). For example, with the addition of 20 mol% of PSO₄, the saturation point was shifted to ~70 wt% water compared to ~40 wt% for pure DPPC and 47 wt% for DPPC-cholesterol. The effectiveness of PSO₄ in fluidizing the membrane and enhancing its hydration state can be useful in the pharmaceutical and cosmetic industries.

Original language	English
Pages (from-to)	763-771
Number of pages	9
Journal	Journal of oleo science
Volume	67
Issue number	6
DOIs	https://doi.org/10.5650/jos.ess17225
Publication status	Published - 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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title = "Effects of β-sitosteryl sulfate on the hydration behavior of dipalmitoylphosphatidylcholine",

abstract = "We investigated the hydration behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers containing sodium β-sitosteryl sulfate (PSO4). PSO4 was found to enhance hydration in the headgroup region of DPPC bilayers. Therefore, with the incorporation of PSO4 into DPPC membranes, the amount of water required to reach the fully hydrated state was enhanced as indicated by the constant values of the main phase transition temperature (Tm) and the bilayer repeat distance (d). For example, with the addition of 20 mol% of PSO4, the saturation point was shifted to ~70 wt% water compared to ~40 wt% for pure DPPC and 47 wt% for DPPC-cholesterol. The effectiveness of PSO4 in fluidizing the membrane and enhancing its hydration state can be useful in the pharmaceutical and cosmetic industries.",

author = "Ananda Kafle and Takeshi Misono and Avinash Bhadani and Masaaki Akamatsu and Kenichi Sakai and Chihiro Kaise and Teruhisa Kaneko and Hideki Sakai",

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AU - Kafle, Ananda

AU - Misono, Takeshi

AU - Bhadani, Avinash

AU - Akamatsu, Masaaki

AU - Sakai, Kenichi

AU - Kaise, Chihiro

AU - Kaneko, Teruhisa

AU - Sakai, Hideki

PY - 2018

Y1 - 2018

N2 - We investigated the hydration behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers containing sodium β-sitosteryl sulfate (PSO4). PSO4 was found to enhance hydration in the headgroup region of DPPC bilayers. Therefore, with the incorporation of PSO4 into DPPC membranes, the amount of water required to reach the fully hydrated state was enhanced as indicated by the constant values of the main phase transition temperature (Tm) and the bilayer repeat distance (d). For example, with the addition of 20 mol% of PSO4, the saturation point was shifted to ~70 wt% water compared to ~40 wt% for pure DPPC and 47 wt% for DPPC-cholesterol. The effectiveness of PSO4 in fluidizing the membrane and enhancing its hydration state can be useful in the pharmaceutical and cosmetic industries.

AB - We investigated the hydration behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers containing sodium β-sitosteryl sulfate (PSO4). PSO4 was found to enhance hydration in the headgroup region of DPPC bilayers. Therefore, with the incorporation of PSO4 into DPPC membranes, the amount of water required to reach the fully hydrated state was enhanced as indicated by the constant values of the main phase transition temperature (Tm) and the bilayer repeat distance (d). For example, with the addition of 20 mol% of PSO4, the saturation point was shifted to ~70 wt% water compared to ~40 wt% for pure DPPC and 47 wt% for DPPC-cholesterol. The effectiveness of PSO4 in fluidizing the membrane and enhancing its hydration state can be useful in the pharmaceutical and cosmetic industries.

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Effects of β-sitosteryl sulfate on the hydration behavior of dipalmitoylphosphatidylcholine

Abstract

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