Effects of β-sitosteryl sulfate on the hydration behavior of dipalmitoylphosphatidylcholine

Ananda Kafle, Takeshi Misono, Avinash Bhadani, Masaaki Akamatsu, Kenichi Sakai, Chihiro Kaise, Teruhisa Kaneko, Hideki Sakai

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We investigated the hydration behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers containing sodium β-sitosteryl sulfate (PSO4). PSO4 was found to enhance hydration in the headgroup region of DPPC bilayers. Therefore, with the incorporation of PSO4 into DPPC membranes, the amount of water required to reach the fully hydrated state was enhanced as indicated by the constant values of the main phase transition temperature (Tm) and the bilayer repeat distance (d). For example, with the addition of 20 mol% of PSO4, the saturation point was shifted to ~70 wt% water compared to ~40 wt% for pure DPPC and 47 wt% for DPPC-cholesterol. The effectiveness of PSO4 in fluidizing the membrane and enhancing its hydration state can be useful in the pharmaceutical and cosmetic industries.

Original languageEnglish
Pages (from-to)763-771
Number of pages9
JournalJournal of oleo science
Issue number6
Publication statusPublished - 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)


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