TY - JOUR
T1 - Effective solitary hyperthermia treatment of malignant glioma using stick type CMC-magnetite. In vivo study
AU - Ohno, Takanari
AU - Wakabayashi, Toshihiko
AU - Takemura, Atsuhito
AU - Yoshida, Jun
AU - Ito, Akira
AU - Shinkai, Masashige
AU - Honda, Hiroyuki
AU - Kobayashi, Takeshi
N1 - Funding Information:
This study was partially funded by a Grant-in-Aid for Scientific Research (C) on Priority Areas (No. 11671365) from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2002
Y1 - 2002
N2 - Various kinds of hyperthermic treatment for malignant glioma had been inhibited due to both their incomplete feverish action and strict cooling effect of the brain. The author shows an effective results of hyperthermia for the treatment of malignant glioma in an in vivo study using stick type carboxymethylcellulose (CMC)-magnetite, a newly manufactured magnetite-product. A stick type CMC-magnetite, containing magnetite particles, was inserted into the T-9 glioma in the rat brain stereotactically, and the rats were exposed to an alternative magnetic field (AMF). The application time of AMF, which measured 88.9 kHz and 380 Oe, was 30 min a day. The rats were divided into three groups: three AMF applications (group I), one AMF application (group II) and no application but only injection of CMC-magnetite (control). As a result, the mean survival in days of these three groups measured 44.2 ± 10.9 (group I), 17.0 ± 1.5 (group II) and 14.4 ± 1.5 (control). This investigation showed both significant effectiveness in attacking malignant glioma and significant prolonging of the survival time in rats. It is also a characteristics feature of the magnetite particles to spread through the tumor diffusely after three applications of AMF. This feature seemed to be one of the main factors that caused greater hyperthermic effect on glioma in this study. This method of hyperthermic treatment could be a useful strategy in the treatment of malignant glioma.
AB - Various kinds of hyperthermic treatment for malignant glioma had been inhibited due to both their incomplete feverish action and strict cooling effect of the brain. The author shows an effective results of hyperthermia for the treatment of malignant glioma in an in vivo study using stick type carboxymethylcellulose (CMC)-magnetite, a newly manufactured magnetite-product. A stick type CMC-magnetite, containing magnetite particles, was inserted into the T-9 glioma in the rat brain stereotactically, and the rats were exposed to an alternative magnetic field (AMF). The application time of AMF, which measured 88.9 kHz and 380 Oe, was 30 min a day. The rats were divided into three groups: three AMF applications (group I), one AMF application (group II) and no application but only injection of CMC-magnetite (control). As a result, the mean survival in days of these three groups measured 44.2 ± 10.9 (group I), 17.0 ± 1.5 (group II) and 14.4 ± 1.5 (control). This investigation showed both significant effectiveness in attacking malignant glioma and significant prolonging of the survival time in rats. It is also a characteristics feature of the magnetite particles to spread through the tumor diffusely after three applications of AMF. This feature seemed to be one of the main factors that caused greater hyperthermic effect on glioma in this study. This method of hyperthermic treatment could be a useful strategy in the treatment of malignant glioma.
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U2 - 10.1023/A:1015080808031
DO - 10.1023/A:1015080808031
M3 - Article
C2 - 12061729
AN - SCOPUS:0036255884
SN - 0167-594X
VL - 56
SP - 233
EP - 239
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 3
ER -
