Effect of Vaccinium ashei reade leaf extracts on lipid metabolism in obese OLETF rats

Nao Inoue, Koji Nagao, Saori Nomura, Bungo Shirouchi, Masashi Inafuku, Hideaki Hirabaru, Noriaki Nakahara, Shoko Nishizono, Takashi Tanaka, Teruyoshi Yanagita

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20 Citations (Scopus)


The effects of a hot water extract and fractional extracts from rabbiteye blueberry (Vaccinium ashei reade) leaves (BBL) on lipid metabolism were studied in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Feeding the hot water extract and fractional extracts from BBL alleviated hepatic triglyceride accumulation in the rats. Additionally, feeding with the flavonol glycoside (FG) and proanthocyanidin (PA) fractions lowered serum cholesterol levels in the obese rats. The results from measurements of the hepatic enzyme activity indicate that the hypolipidemic effects of the hot water extract and the PA fraction might be attributable to enhanced lipolysis in the liver. The reduced serum levels of C-reactive protein, an inflammatory cytokine, by the chlorogenic acid + rutin fraction and FG fraction might be associated with alleviating the metabolic abnormalities in obese rats. These results indicate that the BBL extracts, and especially FG and PA, exerted hypolipidemic effects on obese OLETF rats and suggest that an infusion of BBL can be useful as a dietary hypolipidemic component.

Original languageEnglish
Pages (from-to)2304-2308
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number12
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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