TY - JOUR
T1 - Effect of Toki-Shakuyaku-San on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats
AU - Hatip-Al-Khatib, Izzettin
AU - Hatip, Funda Bölukbaşi
AU - Yoshimitsu, Yoshitaka
AU - Iwasaki, Katsunori
AU - Egashira, Nobuaki
AU - Liu, An Xin
AU - Mishima, Kenichi
AU - Fujiwara, Michihiro
PY - 2007/3
Y1 - 2007/3
N2 - The effects of Toki-shakuyaku-san (TSS) ingredients on acetylcholine (ACh) release in the dorsal hippocampus (DH) were investigated in intact and twice-repeated ischemic rats using in vivo microdialysis-HPLC. Moreover, the effect of TSS on blood flow was investigated in intact rats using laser Doppler flowmetry. TSS at 300 mg/kg p.o. increased ACh and blood flow after 40 min in intact rats. TSS also increased ACh in ischemic rats but to a lesser extent than in intact rats. These results could suggest that TSS-increased ACh and blood flow in DH may contribute in the cognition improving property of TSS.
AB - The effects of Toki-shakuyaku-san (TSS) ingredients on acetylcholine (ACh) release in the dorsal hippocampus (DH) were investigated in intact and twice-repeated ischemic rats using in vivo microdialysis-HPLC. Moreover, the effect of TSS on blood flow was investigated in intact rats using laser Doppler flowmetry. TSS at 300 mg/kg p.o. increased ACh and blood flow after 40 min in intact rats. TSS also increased ACh in ischemic rats but to a lesser extent than in intact rats. These results could suggest that TSS-increased ACh and blood flow in DH may contribute in the cognition improving property of TSS.
UR - http://www.scopus.com/inward/record.url?scp=33947596095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947596095&partnerID=8YFLogxK
U2 - 10.1002/ptr.2050
DO - 10.1002/ptr.2050
M3 - Article
C2 - 17160971
AN - SCOPUS:33947596095
SN - 0951-418X
VL - 21
SP - 291
EP - 294
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 3
ER -