Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

Shinji Tokuda; Toshihiko Fukuda; Yutaro Kobayashi; Mitsuru Tanaka; Toshiro Matsui

doi:10.1271/bbb.110806

Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

Shinji Tokuda
, Toshihiko Fukuda
, Yutaro Kobayashi
, Mitsuru Tanaka
, Toshiro Matsui

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC₅₀ value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

Original language	English
Pages (from-to)	828-830
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	76
Issue number	4
DOIs	https://doi.org/10.1271/bbb.110806
Publication status	Published - 2012

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.110806

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title = "Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats",

abstract = "Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.",

author = "Shinji Tokuda and Toshihiko Fukuda and Yutaro Kobayashi and Mitsuru Tanaka and Toshiro Matsui",

note = "Funding Information: The authors thank K. Miyazaki and E. B. Byun in the Faculty of Agriculture of Kyushu University for technical assistance. This study was supported in part by Grand-in-Aid (no. 22248014) to TM for scientific study from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

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doi = "10.1271/bbb.110806",

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pages = "828--830",

journal = "Bioscience, Biotechnology and Biochemistry",

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publisher = "Oxford University Press",

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T1 - Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

AU - Tokuda, Shinji

AU - Fukuda, Toshihiko

AU - Kobayashi, Yutaro

AU - Tanaka, Mitsuru

AU - Matsui, Toshiro

N1 - Funding Information: The authors thank K. Miyazaki and E. B. Byun in the Faculty of Agriculture of Kyushu University for technical assistance. This study was supported in part by Grand-in-Aid (no. 22248014) to TM for scientific study from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2012

Y1 - 2012

N2 - Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

AB - Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

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U2 - 10.1271/bbb.110806

DO - 10.1271/bbb.110806

M3 - Article

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AN - SCOPUS:84860162873

SN - 0916-8451

VL - 76

SP - 828

EP - 830

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 4

ER -

Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

Abstract

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