Effect of sweet solutions on pain tolerance threshold in pediatric oral mucosa

Shun ji Shiiba, Eiji Sakamoto, Teppei Sago, Hiroyuki Furuta, Toru Yamamoto, Yukiyo Tada, Kiichiro Yamaguchi, Mitsuhiro Yoshida, Nozomu Harano, Masahito Nunomaki, Yoshihiro Nakatsu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


PURPOSE: We examined the effects of sweet taste stimulation on pain tolerance threshold (PTT) of oral mucosa in children. SUBJECTS AND METHODS: Subjects comprised 10 children (mean age, 7.3±1.2 years) for whom PTT of oral mucosa was measured 2 min after oral administrations of sucrose or xylitol and water. Sine wave current stimulation (2 kHz, 250 Hz and 5 Hz, SWCS) which can stimulate sensory nerve fiber selectively (A, Aδ and C) was used to measure PTT. RESULTS: Sweet taste stimulation with sucrose or xylitol increased oral mucosa PTT in children, but not in adults. No difference in the increased PTT was seen between sucrose and xylitol. CONCLUSIONS: Oral administration of sucrose and xylitol may potentially relieve pain associated with local anesthetic injections in children.Key words Oral mucosa, Pain tolerance threshold (PPT), Sine wave current stimulation, Sucrose, Xylitol.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
Journalpediatric dental journal
Issue number1
Publication statusPublished - 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Dentistry (miscellaneous)


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